The Triple-A Norfolk Tides topped the Indianapolis Indians, and the Double-A Bowie Baysox handled the Connecticut Defenders.
The Single-A Frederick Keys completed a three-game sweep over the Salem Red Sox, and the Single-A Delmarva Shorebirds were swept in a doubleheader by the Asheville Tourists.
The short-season Single-A Aberdeen IronBirds lost to the Hudson Valley Renegades.
The Rookie-level Bluefield Orioles fell to the Princeton Rays in extra innings, and the Rookie-level GCL Orioles failed to score in a loss to the GCL Twins.
Score: Norfolk Tides 6, Indianapolis Indians 5 (Box score)
Recap: Right fielder Jeff Fiorentino was 4-for-4 with two RBIs and a run scored in the Tides' 6-5 victory over Indianapolis at Harbor Park.
Norfolk center fielder Joey Gathright collected two hits and a run scored, and infielder Justin Turner was 2-for-3 with a double, an RBI and a run scored.
Tides starting pitcher Jake Arrieta allowed five runs and 10 hits in six innings. The 23-year-old right-hander struck out six batters and issued one walk.
Score: Bowie Baysox 6, Connecticut Defenders 2 (Box score)
Recap: Designated hitter Paco Figueroa was 2-for-4 with a double, a stolen base, two RBIs and a run scored as the Baysox beat Connecticut, 6-2, at Prince George's Stadium.
Bowie shortstop Robert Valido contributed two RBIs, and first baseman Eric Crozier was 2-for-4 with an RBI and a run scored.
Left fielder Jonathan Tucker was 2-for-5 with a stolen base and a run scored for the Baysox, while center fielder Danny Figueroa added a double, an RBI and a run scored.
Baysox starting pitcher Ryohei Tanaka (1-1) allowed two runs and five hits in seven innings to pick up his first victory in the United States. The 26-year-old right-hander struck out seven batters and issued one walk.
Orioles relief pitcher Chris Ray walked one hitter, but he didn't allow any runs in one inning during an injury rehabilitation assignment for the Baysox.
Score: Frederick Keys 1, Salem Red Sox 0 (Box score)
Recap: Center fielder Matt Angle was 2-for-4 with an RBI in the Keys' 1-0 victory over Salem at Harry Grove Stadium.
Frederick left fielder Tyler Henson was 1-for-3 and scored the game's only run, while third baseman Matt Tucker added a single.
Keys starting pitcher Pedro Beato collected six strikeouts and gave up four hits in seven scoreless innings, but he didn't factor in the decision. Relief pitcher Pat Egan (1-1) tossed the final two innings to pick up the win for Frederick.
Game 1 score: Asheville Tourists 7, Delmarva Shorebirds 5, 7 innings (Box score)
Game 1 recap: Asheville scored six runs in the bottom of the sixth inning to beat the Shorebirds, 7-5, in the first game of the doubleheader.
Delmarva first baseman Elvin Polanco was 3-for-4 with a home run, a double, three RBIs and a run scored, while second baseman L.J. Hoes was 3-for-3 with a double, an RBI and a run scored.
Shorebirds catcher Luis Bernardo added a single and an RBI, and center fielder Xavier Avery was 1-for-3 with a stolen base and a run scored.
Starting pitcher Chris Salberg allowed one run and four hits in five innings for the Shorebirds, and relief pitcher T.R. Keating (5-2) was charged with five runs and five hits in two-thirds of an inning.
Game 2 score: Asheville Tourists 5, Delmarva Shorebirds 4, 10 innings (Box score)
Game 2 recap: Hoes hit a two-run home run, but the Shorebirds were swept in the doubleheader after losing the nightcap, 5-4, to Asheville in 10 innings.
Avery was 3-for-5 with a double and an RBI, while third baseman Tyler Kolodny added three doubles, a stolen base and two runs scored for the Shorebirds.
Delmarva starting pitcher Nathan Moreau allowed two runs and three hits in 3 2/3 innings. The 22-year-old left-hander collected nine strikeouts, issued three walks and hit a batter.
Relief pitcher Brett Bordes (1-1) gave up one run, two hits and two walks in two innings for the Shorebirds.
Score: Hudson Valley Renegades 2, Aberdeen IronBirds 0 (Box score)
Recap: Second baseman Michael Mooney was 2-for-3 with a double, but the IronBirds dropped a 2-0 decision to Hudson Valley at Ripken Stadium.
Aberdeen starting pitcher Tyler Sexton (2-4) gave up two runs and four hits in six innings. The 24-year-old left-hander struck out six batters and issued three walks.
IronBirds right fielder Jason Rook collected the team's only other hit.
Score: Princeton Rays 7, Bluefield Orioles 6, 11 innings (Box score)
Recap: First baseman Mike Flacco was 2-for-6 with his first home run of the season, a two-run shot in the fifth inning, but the Orioles lost, 7-6, to Princeton in 11 innings at Bowen Field.
Bluefield infielder Gary Helmick was 3-for-5 with a solo home run, a double, a stolen base and two runs scored, and catcher Joel Polanco added two hits, two RBIs and a run scored.
Orioles right fielder Luis Ramirez was 2-for-5 with a triple, a stolen base and a run scored, and third baseman Corey Thomas contributed a double, a stolen base and an RBI.
Starting pitcher Justin Moore gave up two runs (one earned), one hit and three walks in 4 1/3 innings for the Orioles, while relief pitcher Thomas Phelps (1-2) allowed one run and two hits in one inning to pick up the loss.
Score: GCL Twins 4, GCL Orioles 0 (Box score)
Recap: Starting pitcher Daurin Tavarez (1-1) allowed two runs (one earned) and four hits in five innings, and the Orioles were blanked, 4-0, by the Twins.
Seven different Orioles players collected a single in the game, but they didn't have any extra-base hits.
Left-hander Tony Butler, who was acquired from the Seattle Mariners in the trade for Erik Bedard before the 2008 season, retired all three batters he faced in his first appearance of the season.