The Triple-A Norfolk Tides lost to the Gwinnett Braves, and the game between the Double-A Bowie Baysox and Harrisburg Senators was rained out.
The Single-A Frederick Keys fell to the Salem Red Sox, and the Single-A Delmarva Shorebirds pounded the Greenville Drive.
The short-season Single-A Aberdeen IronBirds edged the Hudson Valley Renegades.
The Rookie-level Bluefield Orioles were beaten by the Greeneville Astros, and the Rookie-level GCL Orioles topped the GCL Reds in 16 innings.
Score: Gwinnett Braves 5, Norfolk Tides 1 (Box score)
Recap: Starting pitcher Chris Tillman (8-6) allowed four runs and six hits in 3 2/3 innings in the Tides' 5-1 loss to Gwinnett.
The 21-year-old right-hander struck out four batters and issued four walks. Tillman only threw 45 of his 84 pitches for strikes, and he gave up a solo home run to Braves left fielder Brandon Jones with one out in the fourth inning.
Norfolk second baseman Justin Turner was 3-for-4 with a double and an RBI, while center fielder Jeff Fiorentino added two hits and a stolen base.
Tides first baseman Brandon Snyder was 0-for-4, lowering his batting average to .200 in 31 games since being promoted to Triple-A.
Relief pitchers Jim Miller and Ross Wolf each tossed a scoreless inning for the Tides.Bowie Baysox (AA)
Tonight's game between the Baysox and Harrisburg was postponed due to rain. No makeup date was immediately announced, and Bowie returns to Prince George's Stadium to take on the Reading Phillies on Friday night.
Score: Salem Red Sox 4, Frederick Keys 2 (Box score)
Recap: Left fielder Tyler Henson contributed a double and two RBIs, but the Keys lost to Salem, 4-2.
Frederick designated hitter Wally Crancer and second baseman Ryan Adams each collected two hits, and shortstop Pedro Florimon Jr. added a single, a stolen base and a run scored.
Keys starting pitcher Pedro Beato (5-7) gave up three runs and seven hits in five innings. The 22-year-old right-hander struck out three batters and issued two walks.
Score: Delmarva Shorebirds 13, Greenville Drive 8 (Box score)
Recap: Center fielder Xavier Avery was 3-for-6 with two RBIs and two runs scored as the Shorebirds outslugged Greenville, 13-8.
Delmarva third baseman Tyler Kolodny was 2-for-5 with a two-run home run and two runs scored, while designated hitter Elvin Polanco added a solo shot.
Shorebirds left fielder Kyle Hudson picked up three hits, an RBI and a run scored, and second baseman Rodolfo Cardona collected two hits, including a double, and three RBIs.
Shortstop Greg Miclat was 2-for-5 with a stolen base and two runs scored for the Shorebirds, and first baseman Joe Mahoney was 1-for-2 with an RBI, four walks and three runs scored.
Delmarva relief pitcher Brent Allar (1-3) gave up one run and two hits in 2 1/3 innings, and starting pitcher Chris Salberg allowed five runs, four hits and four walks in 2 2/3 innings.
Score: Aberdeen IronBirds 5, Hudson Valley Renegades 4 (Box score)
Recap: Shortstop Garabez Rosa hit a solo home run, and the IronBirds beat Hudson Valley, 5-4, at Ripken Stadium.
Aberdeen center fielder Steve Bumbry was 2-for-3 with a double, a stolen base, an RBI and a run scored, but he also committed his first error of the season.
First baseman T.J. Baxter contributed two hits and an RBI for the IronBirds, and right fielder Brian Conley added a double, an RBI and a run scored.
IronBirds relief pitcher Josh Dowdy (1-0) tossed two scoreless innings to pick up the victory in his first appearance since being promoted from Bluefield.
Starting pitcher Patrick Kantakevich gave up four runs and four hits in five innings for the IronBirds. The 22-year-old right-hander walked four batters and collected four strikeouts.
Score: Greeneville Astros 6, Bluefield Orioles 4 (Box score)
Recap: Starting pitcher Matt Hobgood allowed three runs (one earned), one hit and three walks in two innings, and the Orioles lost to Greeneville, 6-4.
The 18-year-old right-hander struck out three batters and threw a wild pitch, but he didn't factor in the decision.
Orioles shortstop Javier Santana was a home run shy of the cycle, and third baseman Omar Casamayor added two hits.
Bluefield relief pitcher Robert Holloway (2-2) gave up two runs and three hits in one inning.
Score: GCL Orioles 5, GCL Reds 4, 16 innings (Box score)
Recap: Right fielder Jaynnertt Melenciano contributed a double, three RBIs and a run scored in the Orioles' 5-4 win over the Reds in 16 innings.
Orioles first baseman David Anderson was 3-for-5 with an RBI and two runs scored, and third baseman Tyler Stampone added two hits and a run scored.
Starting pitcher Daurin Tavarez gave up one run and six hits in 6 1/3 innings for the Orioles, but he didn't factor in the decision.
Orioles relief pitcher Joshua Goodin (1-0) allowed one run and two hits in two innings. The 22-year-old right-hander struck out three batters and issued one walk.