The Triple-A Norfolk Tides play on the road against the Gwinnett Braves, and the Double-A Bowie Baysox look to snap a four-game losing streak when they face the Harrisburg Senators.
The Single-A Frederick Keys meet the Salem Red Sox, and the short-season Single-A Aberdeen IronBirds host the Mahoning Valley Scrappers at Ripken Stadium.
The Rookie-level Bluefield Orioles take on the Greeneville Astros.
The Single-A Delmarva Shorebirds are idle.
There were several transactions in the Orioles' minor league system over the past two days.
The Baysox placed third baseman Mike Costanzo on the disabled list yesterday.
Outfielder Brian Conley was transferred to Aberdeen from the Shorebirds, and right-handed pitcher Scott Mueller headed from the IronBirds to Delmarva.
Also, outfielder Kraig Binick was promoted from Frederick to the Baysox, while the Keys activated infielder Matthew Tucker from the disabled list.
Right-handed pitcher Josh Dowdy joins Aberdeen from Bluefield, and outfielder Lance West heads to Bluefield from the IronBirds.
at Gwinnett Braves (7 p.m.)
Norfolk: David Pauley (7-7, 3.87 ERA)
Gwinnett: Jonny Venters (0-3, 6.39 ERA)Bowie Baysox (AA)
at Harrisburg Senators (7 p.m.)
Bowie: Brian Matusz (5-0, 2.01 ERA)
Harrisburg: Luis Atilano (4-6, 5.31 ERA)
Record: (12-11 in second half, 43-49 overall)
at Salem Red Sox (7:05 p.m.)
Frederick: Zach Britton (5-4, 2.86 ERA)
Salem: Bryan Price (1-5, 6.86 ERA)
Mahoning Valley Scrappers (7:05 p.m.)
Aberdeen: Nicholas Haughian (1-2, 2.63 ERA)
Mahoning Valley: Clayton Cook (1-1, 3.03 ERA)
Greeneville Astros (7 p.m.)
Bluefield: Vito Frabizio (1-1, 3.00 ERA)