With the scored tied, 3-3, and two outs in the seventh inning, the 25-year-old outfielder hit the home run against Braves relief pitcher Manny Acosta.
Norfolk right-hander David Hernandez struck out six hitters in four innings, but he didn't factor in the decision. The 23-year-old starting pitcher allowed one run and five hits. Tides reliever Fredy Deza (1-0), who was recalled from Bowie earlier in the day, earned the win after giving up two runs in two innings.
First baseman Oscar Salazar was 3-for-4 with a double for Norfolk, and designated hitter Scott Moore collected two RBIs.Bowie Baysox (AA)
First baseman Brandon Snyder was 1-for-4 with a double, but he committed a costly error. The 22-year-old infielder mishandled a ball hit by Akron first baseman Beau Mills, and Santana homered immediately after the miscue.
Erbe only allowed two unearned runs and one hit in six innings. He struck out eight hitters and hit two batters in the loss.
Frederick Keys (A)
Score: Salem Red Sox 5, Frederick Keys 4 (Box score)
Recap: Keys second baseman Matthew Tucker and designated hitter Chris Vinyard each hit home runs, but Salem spoiled Frederick's home opener, 5-4, in front of an announced Opening Day-record 6,281 fans at Harry Grove Stadium.
Frederick starting pitcher Tim Bascom (1-1) suffered the loss after giving up four runs (three earned) and seven hits in five innings. The 24-year-old right-hander surrendered two home runs in the loss.
Tucker finished 2-for-5 with two RBIs and two runs scored. Center fielder Matt Angle and third baseman Tyler Henson also added two hits each for the Keys.
Delmarva Shorebirds (A)
Score: Lake County Captains 5, Delmarva Shorebirds 3 (Box score)
Recap: Lake County scored two unearned runs in the top of the ninth inning to edge the Shorebirds, 5-3.
Delmarva shortstop Greg Miclat committed a throwing error that allowed leadoff hitter Chris Nash to reach base for the Captains. Two singles and a wild pitch by Shorebirds relief pitcher Colin Allen (0-1) led to the two runs.
Allen collected three strikeouts, but allowed the two unearned runs and two hits in two innings for the Shorebirds. Starting pitcher Ryan O'Shea gave up three runs and seven hits in six innings for Delmarva. The 22-year-old right-hander struck out two hitters and hit a batter.
Shorebirds designated hitter Brendan Monaghan was 2-for-4 with two RBIs, while right fielder Ronnie Welty scored a run for the sixth time in eight games.