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Last week: 6-8-2

Overall: 60-89-9

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Six-pack: 24-38-4

Six-pack: Jets, Giants, Bengals, Falcons, Patriots, Colts

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Jaguars at Bills

You should know that... J.P. Losman threw for 340 yards and three touchdowns last week against the Texans. Don't expect a repeat performance. Jacksonville's pass defense ranks fifth in the NFL, and the Jaguars made Eli Manning look foolish on Monday night.

The pick: Buffalo (+3)

Texans at Jets

You should know that... It's time for reader Mike T.'s weekly bash:

Your picks last week were awful.  I'm running out of adjectives and metaphors for this mess you've made.

Hints: Bears on a three game road trip...not good; Rams and Giants with big O-line problems...not good either; and finally, ride the big numbers.....2-0 last week and you only took one.

The pick: New York (-4.5)

Steelers at Ravens

You should know that... Hines Ward is listed as questionable for this one. The biggest weakness of the Ravens' defense this season has been its inability to stop big plays in the passing game. I'm thinking this game is going to be a little more high scoring than most people think. I could see Ben Roethlisberger putting up solid yardage numbers, but there's no reason to believe he can take care of the ball. 27-21 Ravens.

The pick: Baltimore (-3)

Bengals at Browns

You should know that... Chad Johnson's 450 total receiving yards in two games are the most ever in NFL history. He faces Cleveland, Baltimore and Oakland the next three weeks. All three teams have pass defenses that rank in the top-10. Let's see if Ocho Cinco can keep up this pace.

The pick: Cincinnati (-3)

Cardinals at Vikings

You should know that... If you're a Donovan McNabb owner who's scrambling for a quarterback to add, Matt Leinart isn't a bad option this week. He's thrown for at least 200 yards in five of six starts and is facing a Minnesota pass defense that ranks 26th in the NFL.

The pick: Minnesota (-6.5)

49ers at Rams

You should know that... San Francisco has won three straight and is 5-5 on the season. The 49ers have allowed 14 points or fewer in their last three games. On offense, it's been all Frank Gore. He's run for 371 yards in his last two games. Meanwhile, Marc Bulger has thrown just one touchdown in his last three games, and Steven Jackson hasn't run for 100 yards since week two. Part of their struggles can be attributed to the season-ending injury suffered by tackle Orlando Pace.

The pick: San Francisco (+5)

Saints at Falcons

You should know that... Drew Brees is the No. 1 fantasy quarterback this season. He's thrown for at least 300 yards in four straight weeks and is facing the 29th-ranked pass defense in the NFL. Marques Colston is questionable with a hurt ankle. If he's inactive, Devery Henderson is not a bad option for a fill-in starter at wide receiver.

The pick: Atlanta (-3)

Panthers at Redskins

You should know that... Jake Delhomme is the 13th-ranked fantasy quarterback and has been a disappointment this season. He's thrown interceptions in five straight games and has just one 300-yard performance this year. If Delhomme can't put up numbers against Washington's 30th-ranked pass defense, he can't do it against anybody.

The pick: Washington (+4)

Bears at Patriots

You should know that... NBC executives have to be killing themselves. The network chose to move the Eagles-Colts game to primetime when it thought Donovan McNabb would be squaring off against Peyton Manning. Instead, it's Jeff Garcia behind center for Philadelphia. The Bears-Patriots game would be the obvious marquee matchup of week 12 if NBC got to choose over again.

The pick: New England (-3)

Eagles at Colts

You should know that...This is NBC's marquee matchup on NBC! Indianapolis is coming off its only loss of the season. The Eagles are relying on Garcia at quarterback. And Peyton Manning has historically torched the Philadelphia defense. Not sure how this line isn't double-digits.

The pick: Indianapolis (-9)

Giants at Titans

You should know that... Eli Manning has been awful over the last six weeks. He's tossed five interceptions and two touchdowns in his last three games and has passed for more than 200 yards just once in his last six. It's tough to bench him here though against the league's 28th-ranked pass defense.

The pick: New York (-3)

Raiders at Chargers

You should know that... After the Raiders lost to the Broncos in week 10, LaMont Jordan told the San Francisco Chronicle that Oakland only had three different running plays available during that game. So let me get this straight. The Raiders have three different running plays available, and they are 2-8. Meanwhile, the Redskins have a dictionary-sized playbook, and they are 3-7. I'm thinking a middle ground would be a good idea here.

The pick: Oakland (+13.5)

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