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David Caruso (Det. John Kelly) of "NYPD Blue"

New York City Police DepartmentJimmy SmitsMark-Paul GosselaarJohn Kelly
The show was all about Caruso when it began in 1993. But Caruso parted ways after one season, making way for a 12-year-long ensemble series that would give Kelly's partner, Det. Andy Sipowicz three more partners -- Jimmy Smits, Rick Schroder, and Mark-Paul Gosselaar.