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'Grey's Anatomy' (ABC)

Premieres: Thursday, Sept. 24 Expect to See: T.R. Knight won't be back as George, but Katherine Heigl apparently lives on as Izzie. Jessica Capshaw will get more exposure as Callie's (Sara Ramirez) romantic interest, Arizona, since she's been signed as a regular for the show's sixth year, and Ellen Pompeo evidently will remain a presence throughout the season -- though her first child is due this fall. Martha Plimpton is set to play a patient's mother in multiple episodes. Related: T.R. Knight: Why I quit 'Grey's Anatomy' Zap2it's Fall TV preview ABC