Samantha Who? (ABC) Returns Monday, April 7 at 9:30 p.m. So Far This Season: Samantha Newly (Christina Applegate) wakes up from a coma to discover she has retrograde amnesia: She doesn't remember her parents, her friends -- or the horrible person she used to be. Sam then takes on the gradual process of piecing her life back together, trying to be better despite the bad influence of best friend Andrea (Jennifer Esposito) and finding a place for ex-boyfriend Todd (Barry Watson), whom she finds herself falling for again. When It Returns: Sam faces eviction for subletting her apartment so she moves back in with the current occupants -- Todd and his new girlfriend. Christina Applegate on 'Samantha Who?' Photo courtesy of ABC.