Samantha Who? (ABC) Returns Monday, April 7 at 9:30 p.m. So Far This Season: Samantha Newly (Christina Applegate) wakes up from a coma to discover she has retrograde amnesia: She doesn't remember her parents, her friends -- or the horrible person she used to be. Sam then takes on the gradual... Christina Applegate on 'Samantha Who?' Photo courtesy of ABC.