Designer Nate Berkus, who's made numerous appearances on Winfrey's daytime talk show, will serve as host of the series, in which contestants mount philanthropic projects in an effort to become the "Biggest Giver." It's scheduled to premiere Sunday, March 2.
"Who wouldn't want to be a part of a show whose entire premise is what you can do for other people?" Berkus says of his new gig. "I think it's fantastic."
The show has also assembled its panel of judges. Chef-author-philanthropist Jamie Oliver, NFL star Tony Gonzalez and Malaak Compton-Rock -- the wife of comedian Chris Rock and founder of the the charity styleWORKS -- will determine who goes home each week.
Over the course of the "Big Give," 10 people (whose identities will be revealed closer to the premiere date) will compete to see who can mount the most creative and effective efforts to help people in need. Each challenge will take place in a different city.
Winfrey, who's an executive producer of the show, will make appearances throughout its run and enlist some of her celebrity pals to appear as well. The winner will receive an undisclosed "major prize" for his or her efforts.
Ellen Rakieten, Harriet Seitler and Jonathan Sinclair created the show and will exec produce with Winfrey and "Amazing Race" veterans Bertram van Munster and Elise Doganieri.