Steven Sommers is directing the project, which now focuses on G.I.J.O.E. or Global Integrated Joint Operating Entity, an international organization of operatives out to fight a terrorist organization called Cobra.
As fans of the classic animated series and action figures recall, Destro is a steel mask-wearing arms dealer, the latest in a long line of Scottish gun-runners.
Set to open on Aug. 7, 2009, the "G.I. Joe" cast also includes Channing Tatum, Dennis Quaid, Sienna Miller, Ray Park, Rachel Nichols, Marlon Wayans, Adewale Akinnuoye-Agbaje, Said Taghmaoui and Joseph Gordon-Levitt.
Eccleston, actually born in Lancashire in the UK, was most recently seen as the occasionally invisible Claude on NBC's "Heroes." The veteran of a season as star of "Doctor Who," Eccleston's other credits include "Jude," "Elizabeth" and "The Seeker."