Indianapolis stayed in the thick of the AFC playoff chase with their fifth straight win. Mathis' big play helped bail out Peyton Manning and Indy's high-octane offense, which failed to score a TD.
The Browns (4-8) lost their fourth straight at home and may have lost quarterback Derek Anderson and tight end Kellen Winslow for an extended period.
Winslow went out on the first play of the third quarter with an ankle injury. Anderson injured his left leg in the final two minutes. Third stringer Ken Dorsey came in for the final three plays and was intercepted on the Browns' last snap.