Fire officials say the blaze began around 8:45 a.m. in the basement of 37-20 30th Avenue in Astoria, and was initially declared a three-alarm fire.
The fire quickly increased to four-alarms and climbed up all three floors, including the street front eatery Flo Lounge Restaurant and residential apartments above it.
All firefighters were recalled from the the inside of the building due to intense flames and smoke conditions, and firefighters were forced to battle the blaze from the outside of the building.
By 11:30 p.m., the fire was declared under control.
Thirteen firefighters were injured and transported to area hospitals in Queens with non-life threatening injuries. All residents were evacuated from the building and one person was treated at the scene.
The cause of the fire is under investigation.