Some of the more than a hundred people will get to work Wednesday at Kohls.
Mayor David Bowers cut the ribbon just after 6:45 Wednesday morning.
He also bought the first tie from the store and threw the old one to the crowd.
Shoppers were already lined up waiting to get in and shop.
Kohl's is off Franklin Road in what was a Walmart in South Roanoke.
The store is creating about 130 new jobs.