Very little separated San Jose and Anaheim in the regular season, with the Ducks edging out the Sharks by one point for second place in the Pacific Division.
Their first-round series wasn't nearly as competitive.
The Sharks rode their superior depth, potent power play and stellar goaltending from Martin Jones to the second sweep in franchise history, knocking out the Ducks with a 2-1 victory on Wednesday night.
"We're playing well going into the second round," defenseman Marc-Edouard Vlasic said. "Everybody is contributing if it's offensively, blocking shots, taking a hit. Everybody is doing what they have to for us to win."