The actioner, that will star Henry Cavill as Superman and Ben Affleck as Batman, will spend around $131 million in the state, the organization said Thursday.
Project is expected to hire 406 Michigan workers, 500 vendors and thousands of extras, the MFO said. The production is expected to spend around $5.1 million on local hotels.
"Detroit is a great example of a quintessential American city, and I know it will make the perfect backdrop for our movie," said director Zack Snyder in a statement.
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The Superman-Batman film is the latest major tentpole to shoot in Michigan since the state revamped its incentives program to entice more films and TV shows to set up shop there. Paramount's "Transformers 4," recently filmed in Detroit.
Disney's "Oz the Great and Powerful" was awarded nearly $40 million to film in Pontiac's Michigan Motion Picture Studios in 2011. Production spent around $105 million in the state.
The funds for the Superman-Batman pic will come from the MFO's fiscal 2014 budget, which has $50 million a year to work with.
The rest of the funds can be used for other projects, including AMC's drama "Low Winter Sun," which received around $9 million for its first season.
The fiscal 2013 budget has awarded $36 million so far in incentives to 26 projects, including "Sun" and "Transformers 4."
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