"Real Time With Bill Maher" has lined up Ann Coulter and Rob Lowe as interview guests this week.

The show airs live at 10 p.m. Friday on HBO and repeats immediately at 11 p.m.

Conservative author Coulter has blasted Republicans for attacking their own and suggested that those party members become Democrats. Coulter's latest book is "Never Trust a Liberal Over 3 -- Especially a Republican." Her targets include Sens. Marco Rubio, John McCain and Lindsey Graham.

Coulter will be the top-of-the-show guest, and actor Lowe of "Parks and Recreation" will be the midshow interview. Lowe is playing President John Kennedy in "Killing Kennedy," which premieres Nov. 10 on National Geographic Channel.

The panel will be director Rob Reiner, astrophysicist Neil deGrasse Tyson and U.S. Rep. Debbie Wasserman Schultz, D-Fla.