The Lakers made a game of it through the first half, playing well defensively, but their lack of playmaking proved crippling in the third period.
For the game, the Lakers shot just 32.5% from the field with 24 turnovers. Nick Young led all scorers with 20 points.
Andrew Bogut had a huge night defensively for Golden State, pulling in a game-high 20 rebounds with 12 points and two blocks. David Lee led the Warriors with 19 points as the home team shot 38.8% from the field with 18 turnovers.
Marreese Speights was ejected in the fourth quarter for his second flagrant foul when he essentially tackled Young.
Kendall Marshall's debut with the Lakers didn't amount to much: two turnovers in three minutes -- although he converted a three-point attempt in the final minutes of the blowout.
With the loss, the Lakers fall back below .500 to 13-14. They'll travel to Phoenix to play the Suns on Monday.
The Warriors (15-13) take a 2-1 season series lead over the Lakers. They'll also play Monday, visiting the Denver Nuggets.
The dam finally broke for the Lakers in third quarter, falling behind by double-digits on the road, second night of a back-to-back without any of their playmakers.
The Lakers shot just 28.6% from the field with 18 turnovers through three quarters, led by Jordan Hill with 14 points and 10 rebounds.
Chris Kaman had 14 rebounds but just eight points on 4-of-16 shooting.
The Lakers' defense kept them close for a half. The Warriors shot just 36.8% from the field through three quarters with 15 turnovers. The Lakers just couldn’t buy a basket in the third.