The game was close at halftime, and then it wasn't, as the Lakers' offense stifled for the last 24 minutes by the league's top-ranked defense.
The Pacers own the NBA's best overall (43-13) and home records (27-3).
The Lakers (19-38) fell further behind the Sacramento Kings for the Western Conference's worst record.
Kent Bazemore had his third career-high in as many games, scoring 23 points, though he made only eight of 19 shots.
In the first half, the Lakers seemed happy to be away from Staples Center, where they have lost nine of their last 10 games.
They trailed the Pacers at halftime, 57-54, but their offense faltered from there as they got careless with the ball (seven turnovers in the third quarter).
They gave ground badly in the third quarter and trailed going into the fourth, 91-70, Tuesday at Bankers Life Fieldhouse.
Turnovers were the main problem, the Lakers committing eight in the quarter, along with an almost predictable slow-down in scoring. The Lakers managed only 16 points in the third, making six of 18 shots against the NBA's top defense.
Kent Bazemore was on his way to a third career-high in his last three games, but his scoring touch stalled after 13 points in the first half. Bazemore missed all four of his third-quarter shots and had 15 points going into the final quarter.
The Lakers emerged from the first half and were't overly embarrassed.
Kent Bazemore continued his solid start with the Lakers, scoring 13 points and developing decent chemistry with Pau Gasol, finding him on a couple of occasions after drives.
Gasol, though, had trouble converting, scoring seven points on three-for-nine shooting.