The privilege is only available on certain flights and only six passengers at a time will be able to use the system.
Passengers will be able to send text messages, make a call or access email on mobile devices.
Initially, the service -- which utilizes a satellite connection -- will only be available for customers of European cell phone providers O2 and Vodafone and U.S. carrier T-Mobile.
The service debuted Tuesday on the airline's new Airbus A330-300 planes flying between New York and London.
The airline won't charge extra for the service, but cell phone users will be charged their carrier's international roaming rates.
Dubai-based Emirates became the first carrier to allow passengers to use their personal cell phones back in 2008.
This new phone service is part of a larger $160 million dollar upgrade of the airline's Upper Class cabin, although it will be also available to passengers in coach.
Calls are not permitted during take-off or landing or within 250 miles of U.S. airspace.