More than 19,500 flight have been canceled as a result of the storm, according to flight tracking site FlightAware.com.
FlightAware said that 481 cancellations have been reported so far for Thursday.
Here at home, Los Angeles International Airport cancelled more than 200 arrivals and departures due to the storm.
Officials at LAX reported the cancellation of 27 flights to and from the East Coast on Wednesday due to weather conditions associated with Sandy.
Airport officials warned that the number was fluid and could change at anytime, however.
Passengers were advised to check with their airlines to verify flight schedules before going to the airport.
The status of flights at LAX is available at www.lawa.org/fsw/default.aspx.
Meanwhile, all Jet Blue flights out of Burbank to New York City's John F. Kennedy International Airport were canceled for Wednesday.
On Wednesday morning, both JFK and Newark announced that they had reopened partial service.
LaGuardia is expected to remain closed through Wednesday becasue of significant damage.
Delta Air Lines said it expected to resume limited domestic service to JFK on Wednesday afternoon.
The Boston and Philadelphia airports and the three airports serving the Washington/Baltimore area are open and operational, with some airlines already resuming limited flight service.
Southwest Airlines (and subsidiary AirTran Airways) planned to resume normal operations by midday Wednesday across the Northeast and mid-Atlantic region.
The exceptions were the New York City-area and Philadelphia airports, according to a statement from Southwest.
United previously announced that it hoped to resume service at the major Washington area airports and Cleveland on Tuesday evening, weather permitting.
Most carriers will allow affected passengers to change their itineraries without penalty.
You can check advisories from the major airlines -- American Airlines, Delta, United, US Airways, AirTran, JetBlue and Southwest -- on their websites.
The Federal Aviation Administrations website provides up-to-the-minute conditions at all U.S. airports.
To check airport conditions, go to www.faa.gov and click on "Airport Status and Delays."