(CNN) -- A massive storm system made its way up the Eastern Seaboard Friday, leaving flooded neighborhoods and roadways in its wake.

The storm is forecast to drop heavy rain in the Northeast as the remnants of Tropical Storm Nicole interact with an upper-level low and a frontal boundary.

Flood watches and warnings have been issued from North Carolina to Maine. High-wind warnings were in effect from Massachusetts to Maine, with wind gusts up to 60 mph.

About 150 roads were in North Carolina were closed and some people were evacuated in Bertie County, said Patty McQuillan, communications officer for the state's Department of Crime Control and Public Safety.

Five people died in weather-related incidents, she said. As of 8 a.m. Friday, New York City had received almost 3 inches of rain. Mass transit was recovering from service suspensions and delays.

In Swansboro, North Carolina, eight people were rescued, an emergency management official said. That scene repeated itself in a few other North Carolina and Virginia communities.

Airport delays are expected to be crippling in the Northeast again, with ground stops and delays of three hours or more at the New York City airports and in Boston, Massachusetts.

Baltimore, Maryland -- at 6.02 inches-- on Thursday had its wettest September day ever. Norfolk, Virginia, endured nearly 12 inches of rainfall. CNN affiliate WUSA showed images of flooding in St. Mary's County, Maryland.

Rain left city streets under water, stranded vehicles and sent scores of people to shelters and caused major delays at airports along the East Coast.

Skies were beginning to clear Friday in much of the Carolinas and Virginia.

Wilmington, North Carolina, has received 22.54 inches of rain since Sunday, the National Weather Service said. September's total of 22.72 inches was shy of the record 23.41 inches in 1999.

"Waterwise, it was significant," said Warren Lee, emergency management director for New Hanover County, which includes three beach communities. Monday was actually worse than Thursday, said Lee, because the heavy rain hit bone-dry ground and sparked flash flooding.

Crews will do a damage assessment Friday, he said, indicating there were few evacuations and little wind damage.

Sixty miles up the coast, there was extensive flooding in Swansboro, according to Norman Bryson with Onslow County Emergency Management. The town was completely cut off to vehicular traffic.

A weather-related accident claimed four lives in Washington County where a Jeep Grand Cherokee hydroplaned and ended up in a ditch filled with water. Four of five people in the SUV drowned. They were from Gwinnett County, Georgia.

A 3-year-survived and was hospitalized Friday, officials said.

In Carolina Beach, a lake overflowed and flooded downtown, a video from CNN affiliate WRAL showed one person kayaking through the streets. U.S. 421 remained closed Friday morning.

Carolina Beach Town Manager Tim Owens said the weather was improving Friday and the town expects tourists to return for the weekend. He said some residents near the retention lake likely have some flood damage. "We fared pretty well," he said.

CNN iReporters snapped flood photos and told their tales.

In upstate New York, Esopus Creek, a tributary of the Hudson River, overflowed and flooded shops and homes in downtown Phoenicia, said Kevin Keaveny.

"I've never seen the water come up to the streets," he said.

Margaret Pelczynski of Buffalo, New York, was visiting Carolina Beach. "This only confirms my beliefs that I'd gladly take a blizzard any day over this rain, wind and flooding," she wrote.

And William Bernstein Jr. posted photos of Virginia Beach, Virginia. He said there were rescues Thursday and trees down in the Tidewater area. "I believe this will be one we will remember a long time," he wrote.

The American Red Cross opened seven shelters in North Carolina for those displaced by floods, the group said Thursday.

In Norfolk and Portsmouth, Virginia, many streets were flooded, as were stretches of Interstate 264, according to CNN Virginia affiliate WAVY 10. Some in the area are without power because of downed lines.

Flood watches and warnings were in effect for Friday for all or major parts of Maryland, Delaware, Pennsylvania, New Jersey, New York, Vermont, New Hampshire and Maine, according to the National Weather Service.

Police in Wilmington, Delaware, warned motorists about areas of high water Friday.

Wind gusts of up to 50 miles per hour are expected in parts of New Jersey, New York and Connecticut, the National Weather Service said.

The rain will move out of the Northeast throughout Friday, but not before dropping an additional 4-6 inches (100-150 mm), according to CNN Meteorologist Taylor Ward.