Peyton Manning is making this look easy.

He led the Colts to touchdowns on four of their first five drives Sunday, tied milestones established by Fran Tarkenton and Dan Marino and extended Indianapolis' regular-season victory streak to 13 with a 34-17 win over Seattle.

Manning finished 31 of 41 for 353 yards, marking the first time in 12 NFL seasons he has topped 300 yards in four consecutive games.

The first TD pass went to Reggie Wayne, making Manning and Dan Marino the only quarterbacks in league history to throw 55 TD passes to two different receivers. The second went to rookie Austin Collie after a brilliant audible with 3 seconds left in the half. It not only gave the Colts a 21-3 halftime lead but also gave Manning a share of third place on the NFL's career touchdowns passing list with Tarkenton. Both have 342.

Only Marino (420) and Brett Favre (469) have thrown more.

Seattle (1-3) played without quarterback Matt Hasselbeck and left tackle Walter Jones, who are both hurt, and lost its third straight.

But Manning and the Colts (4-0) made sure it was no contest.

Manning was so good in the first half that only 3 of his 20 passes hit the ground. One was a throwaway, another was batted at the line.

Indy's defense limited Seattle to just 49 yards rushing, Seneca Wallace was 33 of 45 for 257 yards, lost a fumble and was sacked five times, including once by Dwight Freeney who played after reports earlier this week indicated he would miss two to three weeks.

Manning took control from the start, moving the Colts 80 yards on their opening drive. Donald Brown capped it with a 1-yard TD run for a 7-0 lead.

Indy ran just three more plays in the quarter, but when the Colts got the ball back in the second, Manning demonstrated his efficiency. This time the Colts went 90 yards in nine plays, the last five coming on Manning's scoring pass to Wayne for a 14-0 lead with 5:29 left in the half.

Seattle got a 38-yard field goal from Olindo Mare with 1:22 to go, but that was too much time for Manning.

He took the Colts 78 yards in nine plays and beat the clock with a 21-yard TD pass to Collie.

Joseph Addai's 12-yard run in the third quarter and two Adam Vinatieri field goals sealed the outcome.

The Seahawks didn't make it into the end zone until the final three minutes. Wallace scored on a 7-yard run with 2:59 to go, and after recovering an onside kick, Wallace threw a 1-yard TD pass to Owen Schmitt.