WILLIAMSBURG ─ Pick your favorite mismatch: Reagan and Mondale; Hurricane Katrina and New Orleans; Rex Ryan and a box of Krispy Kremes. None approach William and Mary-VMI.

A one-year hiatus did little to make the series between the longtime rivals more competitive. The Tribe did pretty much what it wanted, when it wanted Saturday and extended a remarkable run of dominance.

William and Mary's 45-0 victory at Zable Stadium makes it 24 in a row against the Keydets dating back to 1985, and the games haven't been close in quite a while.

"I was pleased with the fact that we bounced back and took care of business," Tribe coach Jimmye Laycock said, whose team lost its opener the week before at Massachusetts. "Especially defensively, I really thought we came back and started playing better defensively.

"It still wasn't as good as it needs to be. We still gave up some yardage, but we were able to maintain our focus and keep the shutout going, which was big. We were able to get some turnovers tonight, which we were talking about (that) we needed to do, and we played a lot of people."

The Tribe has scored at least 34 points in the past 14 meetings versus VMI, and its average margin of victory in the past 17 meetings is 33.1 points.

The Keydets have had seven different head coaches since they last defeated William and Mary – eight if you count athletic director Donny White, who did a one-game interim gig in 1998 when he pulled the plug on the forgettable Ted Cain era.

Laycock, obviously, is the constant for W&M, and his team handled its outmanned opponent. The Tribe scored on offense, defense and special teams. The highlights were five interceptions by the defense, B.W. Webb's punt return for a touchdown and quarterback Mike Callahan's accuracy (12-for-17, 234 yards, one touchdown) and consistent efficiency.

"We ended up taking over," said Callahan, who had four completions of at least 27 yards. "We got our deep shots going. There were a couple runs here and there we couldn't really get, but I thought we played pretty well."

The Tribe defense again was without all-conference linebacker Jake Trantin. W&M's leading tackler a year ago missed the season opener against UMass because of the effects of a concussion.

On Saturday, he didn't play due to family issues, the athletic staff said, and he also will miss next Saturday's game against Old Dominion.

But Trantin was hardly missed on this particular evening. The Tribe ran out to a 31-0 halftime lead and cruised from there. The Tribe squeezed VMI's quarterback trio of Cam Jones, Adam Morgan and true freshman Eric Kordenbrock.

After leading the Football Championship Subdivision in rushing the past two years, head coach Sparky Woods scrapped VMI's ground-oriented option offense for a more balanced, pro-style attack.

The Keydets threw for 304 yards in their season opening 48-6 win against Division II Lock Haven, but managed just 126 yards passing Saturday, with the five interceptions.

"The pressure was on us," Laycock said, "to play our game and to perform well and take care of business and work to improve, and I thought pretty much we improved this week and into tonight."