All times Central. Home games in CAPS.
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| REGULAR SEASON | | DATE | OPPONENT | RESULT | TV/RECORD |
| 3/31 | MILWAUKEE | L, 4-3 (10 inn.) | 0-1 |
| 4/2 | MILWAUKEE | L, 8-2 | 0-2 |
| 4/3 | MILWAUKEE | W, 6-3 | 1-2 |
| 4/4 | HOUSTON | L, 4-3 | 1-3 |
| 4/5 | HOUSTON | W, 9-7 | 2-3 |
| 4/6 | HOUSTON | W, 3-2 | 3-3 |
| 4/7 | at Pittsburgh | W, 10-8 (12 inn.) | 4-3 |
| 4/9 | at Pittsburgh | W, 6-4 (15 inn.) | 5-3 |
| 4/10 | at Pittsburgh | W, 7-3 | 6-3 |
| 4/11 | at Philadelphia | L, 5-3 | 6-4 |
| 4/12 | at Philadelphia | L, 7-1 | 6-5 |
| 4/13 | at Philadelphia | W, 6-5 (10 inn.) | 7-5 |
| 4/15 | CINCINNATI | W, 9-5 | 8-5 |
| 4/16 | CINCINNATI | W, 12-3 | 9-5 |
| 4/17 | CINCINNATI | L, 9-2 | 9-6 |
| 4/18 | PITTSBURGH | W, 3-2 | 10-6 |
| 4/19 | PITTSBURGH | W, 13-1 | 11-6 |
| 4/20 | PITTSBURGH | W, 13-6 | 12-6 |
| 4/21 | N.Y. METS | W, 7-1 | 13-6 |
| 4/22 | N.Y. METS | W, 8-1 | 14-6 |
| 4/23 | at Colorado | W, 7-6 (10 inn.) | 15-6 |
| 4/24 | at Colorado | L, 4-2 | 15-7 |
| 4/25 | at Washington | L, 5-3 | 15-8 |
| 4/26 | at Washington | W, 7-0 | 16-8 |
| 4/27 | at Washington | L, 2-0 | 16-9 |
| 4/29 | MILWAUKEE | L, 10-7 | 16-10 |
| 4/30 | MILWAUKEE | W, 19-5 | 17-10 |
| 5/1 | MILWAUKEE | L, 4-3 | 17-11 |
| 5/2 | at St. Louis | L, 5-3 (11 inn.) | 17-12 |
| 5/3 | at St. Louis | W, 9-3 | 18-12 |
| 5/4 | at St. Louis | L, 5-3 | 18-13 |
| 5/5 | at Cincinnati | L, 5-3 | 18-14 |
| 5/6 | at Cincinnati | W, 3-0 | 19-14 |
| 5/7 | at Cincinnati | L, 9-0 | 19-15 |
| 5/9 | ARIZONA | W, 3-1 | 20-15 |
| 5/10 | ARIZONA | W, 7-2 | 21-15 |
| 5/11 | ARIZONA | W, 6-4 | 22-15 |
| 5/12 | SAN DIEGO | W, 12-3 | 23-15 |
| 5/13 | SAN DIEGO | L, 4-3 | 23-16 |
| 5/14 | SAN DIEGO | W, 8-4 | 24-16 |
| 5/15 | SAN DIEGO | W, 4-0 | 25-16 |
| 5/16 | PITTSBURGH | W, 7-4 | 26-16 |
| 5/17 | PITTSBURGH | L, 7-6 | 26-17 |
| 5/18 | PITTSBURGH | W, 4-3 | 27-17 |
| 5/19 | at Houston | W, 7-2 | 28-17 |
| 5/20 | at Houston | L, 4-2 | 28-18 |
| 5/21 | at Houston | L, 5-3 | 28-19 |
| 5/23 | at Pittsburgh | W, 12-3 | 29-19 |
| 5/24 | at Pittsburgh | L, 5-4 (14 inn.) | 29-20 |
| 5/25 | at Pittsburgh | L, 6-5 | 29-21 |
| 5/26 | L.A. DODGERS | W, 3-1 | 30-21 |
| 5/27 | L.A. DODGERS | W, 3-1 | 31-21 |
| 5/28 | L.A. DODGERS | W, 2-1 (10 inn.) | 32-21 |
| 5/29 | COLORADO | W, 8-4 | 33-21 |
| 5/30 | COLORADO | W, 10-9 | 34-21 |
| 5/31 | COLORADO | W, 5-4 | 35-21 |
| 6/1 | COLORADO | W, 5-3 | 36-21 |
| 6/2 | at San Diego | W, 7-6 | 37-21 |
| 6/3 | at San Diego | W, 9-6 | 38-21 |
| 6/4 | at San Diego | L, 2-1 | 38-22 |
| 6/5 | at L.A. Dodgers | W, 5-4 | 39-22 |
| 6/6 | at L.A. Dodgers | L, 3-0 | 39-23 |
| 6/7 | at L.A. Dodgers | L, 7-3 | 39-24 |
| 6/8 | at L.A. Dodgers | W, 3-1 | 40-24 |
| 6/10 | ATLANTA | W, 10-5 | 41-24 |
| 6/11 | ATLANTA | W, 7-2 | 42-24 |
| 6/12 | ATLANTA | W, 3-2 (11 inn.) | 43-24 |
| 6/13 | at Toronto | L, 3-2 | 43-25 |
| 6/14 | at Toronto | W-, 6-2 | 44-25 |
| 6/15 | at Toronto | W, 7-4 | 45-25 |
| 6/16 | San Diego at Cooperstown, N.Y. (Ex.) | Ppd. | 45-25 |
| 6/17 | at Tampa Bay | L, 3-2 | 45-26 |
| 6/18 | at Tampa Bay | L, 5-4 | 45-27 |
| 6/19 | at Tampa Bay | L, 8-3 | 45-28 |
| 6/20 | WHITE SOX | W, 4-3 | 46-28 |
| 6/21 | WHITE SOX | W, 11-7 | 47-28 |
| 6/22 | WHITE SOX | W, 7-1 | 48-28 |
| 6/24 | BALTIMORE | L, 7-5 | 48-29 |
| 6/25 | BALTIMORE | W, 7-4 | 49-29 |
| 6/26 | BALTIMORE | L, 11-4 | 49-30 |
| 6/27 | at White Sox | L, 10-3 | 49-31 |
| 6/28 | at White Sox | L, 6-5 | 49-32 |
| 6/29 | at White Sox | L, 5-1 | 49-33 |
| 6/30 | at San Francisco | W, 9-2 | 50-33 |
| 7/1 | at San Francisco | L, 2-1 | 50-34 |
| 7/2 | at San Francisco | W, 6-5 | 51-34 |
| 7/3 | at San Francisco | L, 8-3 | 51-35 |
| 7/4 | at St. Louis | W, 2-1 | 52-35 |
| 7/5 | at St. Louis | L, 5-4 | 52-36 |
| 7/6 | at St. Louis | W, 7-1 | 53-36 |
| 7/8 | CINCINNATI | W, 7-3 | 54-36 |
| 7/9 | CINCINNATI | W, 5-1 | 55-36 |
| 7/10 | CINCINNATI | L, 12-7 | 55-37 |
| 7/11 | SAN FRANCISCO | W, 3-1 | 56-37 |
| 7/12 | SAN FRANCISCO | W, 8-7 (11 inn.) | 57-37 |
| 7/13 | SAN FRANCISCO | L, 4-2 | 57-38 |
| 7/15 | All-Star Game at Yankee Stadium | L, 4-3 (15 inn.) | |
| 7/18 | at Houston | L, 2-1 | 57-39 |
| 7/19 | at Houston | L, 4-1 | 57-40 |
| 7/20 | at Houston | 1:05 p.m. | WGN |
| 7/21 | at Arizona | 8:40 p.m. | CSN |
| 7/22 | at Arizona | 8:40 p.m. | WGN |
| 7/23 | at Arizona | 8:40 p.m. | CSN |
| 7/24 | FLORIDA | 7:05 p.m. | CSN |
| 7/25 | FLORIDA | 1:20 p.m. | WGN |
| 7/26 | FLORIDA | 12:05 p.m. | WGN |
| 7/27 | FLORIDA | 1:20 p.m. | CSN |
| 7/28 | at Milwaukee | 7:05 p.m. | CSN |
| 7/29 | at Milwaukee | 7:05 p.m. | WGN |
| 7/30 | at Milwaukee | 7:05 p.m. | CSN |
| 7/31 | at Milwaukee | 1:05 p.m. | WGN |
| 8/1 | PITTSBURGH | 1:20 p.m. | CSN |
| 8/2 | PITTSBURGH | 12:05 p.m. | CSN |
| 8/3 | PITTSBURGH | 1:20 p.m. | WGN |
| 8/4 | HOUSTON | 7:05 p.m. | WCIU |
| 8/5 | HOUSTON | 1:20 p.m. | CSN |
| 8/6 | HOUSTON | 1:20 p.m. | WGN |
| 8/8 | ST. LOUIS | 1:20 p.m. | CSN |
| 8/9 | ST. LOUIS | 2:55 p.m. | FOX |
| 8/10 | ST. LOUIS | TBD | TBD |
| 8/12 | at Atlanta | 6:10 p.m. | WGN |
| 8/13 | at Atlanta | 6:10 p.m. | CSN+ |
| 8/14 | at Atlanta | 6:10 p.m. | CSN |
| 8/15 | at Florida | 6:10 p.m. | CSN |
| 8/16 | at Florida | 6:10 p.m. | WGN |
| 8/17 | at Florida | 12:10 p.m. | WGN |
| 8/19 | CINCINNATI | 7:05 p.m. | CSN |
| 8/20 | CINCINNATI | 7:05 p.m. | WCIU |
| 8/21 | CINCINNATI | 1:20 p.m. | CSN |
| 8/22 | WASHINGTON | 1:20 p.m. | WGN |
| 8/23 | WASHINGTON | 12:05 p.m. | CSN |
| 8/24 | WASHINGTON | 1:20 p.m. | WGN |
| 8/25 | at Pittsburgh | 6:05 p.m. | CSN |
| 8/26 | at Pittsburgh | 6:05 p.m. | WGN |
| 8/27 | at Pittsburgh | 11:35 a.m. | CSN |
| 8/28 | PHILADELPHIA | 7:05 p.m. | WGN |
| 8/29 | PHILADELPHIA | 1:20 p.m. | CSN |
| 8/30 | PHILADELPHIA | 2:55 p.m. | FOX |
| 8/31 | PHILADELPHIA | TBD | TBD |
| 9/1 | HOUSTON | 3:05 p.m. | WGN |
| 9/2 | HOUSTON | 7:05 p.m. | WGN |
| 9/3 | HOUSTON | 7:05 p.m. | CSN |
| 9/5 | at Cincinnati | 6:10 p.m. | CSN+ |
| 9/6 | at Cincinnati | 6:10 p.m. | CSN |
| 9/7 | at Cincinnati | 12:15 p.m. | WGN |
| 9/9 | at St. Louis | 7:15 p.m. | WGN |
| 9/10 | at St. Louis | 7:15 p.m. | CSN |
| 9/11 | at St. Louis | 7:15 p.m. | CSN |
| 9/12 | at Houston | 7:05 p.m. | CSN+ |
| 9/13 | at Houston | 6:05 p.m. | CSN |
| 9/14 | at Houston | 1:05 p.m. | WGN |
| 9/16 | MILWAUKEE | 7:05 p.m. | CSN |
| 9/17 | MILWAUKEE | 7:05 p.m. | WCIU |
| 9/18 | MILWAUKEE | 1:20 p.m. | CSN |
| 9/19 | ST. LOUIS | 1:20 p.m. | CSN |
| 9/20 | ST. LOUIS | 12:05 p.m. | WGN |
| 9/21 | ST. LOUIS | TBD | TBD |
| 9/22 | at N.Y. Mets | 6:10 p.m. | CSN |
| 9/23 | at N.Y. Mets | 6:10 p.m. | CS N |
| 9/24 | at N.Y. Mets | 6:10 p.m. | WCIU |
| 9/25 | at N.Y. Mets | 6:10 p.m. | CSN |
| 9/26 | at Milwaukee | 7:05 p.m. | CSN |
| 9/27 | at Milwaukee | 12:05 p.m. | WGN |
| 9/28 | at Milwaukee | 1:05 p.m. | WGN |
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Caption Call
2008 British Open
THINGS TO DO