It will mark the second straight year that Maryland opens its season at the venue. The Terps lost, 72-69, to Kentucky on Nov. 9 to start this season.
Sophomore center Alex Len led the Terps with 23 points and 12 rebounds in the loss to the Wildcats, while sophomore guard Nick Faust added 11 points.
Connecticut, which served a one-year postseason ban this season due to low Academic Progress Rate scores, finished tied for seventh in the Big East Conference during the regular season. The Huskies were 20-10 overall, including 10-8 in conference play.
Two weeks ago, Maryland finalized a multiyear agreement to play at the Barclays Center.
The Washington Post first reported the Terps' opponent and date of the 2013 season opener.