The teams will meet in the Jimmy V Women's Classic on Dec. 3, ESPN and The V Foundation for Cancer Research announced Tuesday.
The Huskies will come to College Park for a game against the Terrapins in 2013.
"When I was approached with the opportunity for Maryland to be a part of this event and help cancer research, I jumped at it," Maryland coach Brenda Frese said. "With my son's [Tyler's] fight against leukemia, it's obviously something that has directly affected us. So many people have helped us and we're willing to pay it forward to help any other family dealing with cancer."
"From a basketball end, it won't be hard to get our team motivated. It will be a terrific test on the road. Everyone knows about Connecticut's program and Geno's incredible success. I'm also familiar with the players that will be joining their roster next season. I think it's safe to say they'll be very highly ranked. We plan on being up for the challenge, and I hope it's a game worthy of the cause."
The No. 2 Huskies (7-0), coached by Geno Auriemma, are seven-time national champions. They'll be making their fifth appearance in the Jimmy V Women's Classic. The No. 5 Terps (9-0), who won the national title in 2006, will appear in the Classic for the second time and first since 2007.
ACC teams have made 11 appearances in the event. The league has had a team in the Classic in eight of the 11 years. This will mark the Big East's eighth appearance.
Maryland's next game is at 7 p.m. Thursday against visiting Delaware State (2-6). Maryland junior Tianna Hawkins will play against her twin sister, Tierra, who is the Hornets' leading scorer and rebounder.