Orr, who leads the team with 130 tackles and two fumble recoveries, was taken out briefly in the first quarter of Sunday’s 31-27 loss to the Pittsburgh Steelers after crashing helmets with running back Le’Veon Bell on a run. Orr, who returned to the field later in the series, has not missed a start this season.
Wagner suffered a concussion during the third quarter and missed the entire fourth quarter as he was in the NFL’s concussion protocol. Wagner, who has made 14 starts, was replaced by James Hurst.
Cornerback Jimmy Smith also did not practice, and coach John Harbaugh said Monday that a high right ankle sprain would likely sideline Smith for the third consecutive game.
Left guard Marshal Yanda (left shoulder) was absent, but is likely enjoying a day off as a veteran.
UPDATE: Orr did not practice because of what the team described as a neck ailment in Wednesday’s injury report. Wagner (concussion), Smith (high right ankle sprain), and Yanda (day off) joined Orr as non-participants.
Rookie guard Alex Lewis (high right ankle sprain) took part fully in practice.
The Cincinnati Bengals, Sunday’s opponent, have already ruled out wide receiver A.J. Green, who will miss his sixth consecutive game because of a right hamstring strain.
They practiced Wednesday without three other starters in outside linebacker Vontaze Burfict (concussion, knee), running back Jeremy Hill (knee), and tight end Tyler Kroft (knee, ankle).
Two other starters in cornerback Adam Jones (ankle) and left guard Andrew Whitworth (biceps) participated on a limited basis.