The team has not officially ruled Lewis out of the game, and coach John Harbaugh is expected to address the situation when he meets with the media today.
Lewis, who has been dealing with a toe injury suffered against the Seattle Seahawks on Sunday, sat out practice Wednesday and Thursday.
He also was not practicing today, at least in the portion made available to the media.
A report by the Carroll County Times said Lewis, 36, visited a specialist in Florida for another opinion, which confirmed the damage to his toe.
Lewis, a 12-time Pro Bowl selection and two-time Defensive Player of the Year, has not missed a start since being sidelined for the last two games of the 2007 regular season. He has started 57 consecutive regular-season games.