Starting left tackle Nate Solder (concussion) and backup rookie wide receiver Kenbrell Thompkins (hip) were ruled out Saturday night. This is the third consecutive game Thompkins has missed.
Solder was limited Thursday and Friday in practice. A 2011 first-round draft pick from Colorado, the 6-foot-8, 320-pound Solder has not missed a game in his NFL career.
He left last Sunday's game against the Miami Dolphins in the fourth quarter after absorbing a hit to the head.
The Patriots' top backup tackle is Will Svitek.
Besides Thompkins, the Patriots had already ruled out rookie wide receiver Josh Boyce with an ankle injury.