Kevin Cowherd

Ravens 17, 49ers 10

Even an IV drip of Red Bull won't help the 49ers overcome short work week, six-hour flight to East Coast. Ravens' D gets up for Harbaugh Bowl.

Edward Lee

49ers 16, Ravens 14

The short week and cross-country flight will take their toll on the 49ers, but a Ray Lewis-less defense is not a good formula against Frank Gore.

Mike Preston

Ravens 14, 49ers 10

The short week and long trip from the West Coast are too much for the 49ers to overcome.

Peter Schmuck

Ravens 27, 49ers 16

It's tough enough to play on the opposite coast in the NFL, but doing it on three days' rest is going to leave the 49ers flat.

Kevin Van Valkenburg

Ravens 30, 49ers 17

The Ravens are stellar at home. They have an even bigger advantage with both teams on short rest, and the 49ers having to fly across the country.

Mark Viviano

Ravens 22, 49ers 13

I stick with my prediction that the Ravens go unbeaten at home this year. This game's served on a holiday platter thanks to 49ers' long travel in short week.

Jeff Zrebiec

Ravens 16, 49ers 13

Sibling duels are always volatile and intense and this game will be no different. But John Harbaugh's Ravens will be more physical and the better team on this night.