Here are 10 must-see games during the 2012 college football season:

Boise State at Michigan State

When: Friday, Aug. 31, at 8 p.m.; ESPN

The Buzz: This will be fourth straight season Boise State opens with a tough contest that will immediately decide whether the Broncos can contend for a national championship.

Alabama vs. Michigan at Cowboys Stadium

When: Saturday, Sept. 1, at 8 p.m.; ABC

The Buzz: It’s surprising these two giant college football programs have only met three previous times. Michigan is the underdog in this matchup.

Clemson at Florida State

When: Saturday, Sept. 22; TBA.

The Buzz: A shot at the national championship and the Atlantic Coast Conference’s Atlantic Division title will be on the line.

Wisconsin at Nebraska

When: Saturday, Sept. 29, at 8 p.m.; ABC)

The Buzz: A third straight trip to Pasadena and the Rose Bowl isn’t out of the question for Wisconsin.

Georgia at South Carolina

When: Saturday, Oct. 6; TBA

The Buzz: The SEC East Division crown could be up for grabs during this mid-season matchup.

Notre Dame at Oklahoma

When: Saturday, Oct. 27; TBA

The Buzz: Notre Dame has won eight of the last nine games against Oklahoma, with its sole loss coming in 1956.

Alabama at LSU

When: Saturday, Nov. 3; TBA

The Buzz: LSU is looking to avenge last year’s 21-0 loss to Alabama in the BCS title game.

Oregon at USC

When: Saturday, Nov. 3; TBA

The Buzz: Oregon has been cream of the crop in the Pac-12, but USC is eager to reclaim the top spot.

Florida State at Virginia Tech

When: Thursday, Nov. 8, at 7:30 p.m.; ESPN

The Buzz: This matchup could be a preview of the ACC Championship Game.

Oklahoma at West Virginia

When: Saturday, Nov. 17; TBA

The Buzz: West Virginia’s Dana Holgorsen is all too familiar with the Oklahoma football program, previously serving as Oklahoma State’s offensive coordinator.

mmurschel@tribune.com.