Johnson said he felt pain in the wrist after fouling off a change up in his first at bat on Wednesday in the second inning.
Johnson, who is hitting .209 with four homers and 11 RBIs in 38 games, has had multiple surgeries on the same wrist.
He had his most recent surgery on the wrist in May 2010 while playing for the Yankees. Pain in the wrist lingered through last season while he was playing at Triple-A Columbus. He said just taking batting practice last season would hurt.
"I think everyone's aware of the history, the problems he's had there," Orioles manager Buck Showalter said. "He felt pretty good in BP today."
After Wednesday's game, Johnson said he was optimistic he could stay off the disabled list.
"It’s not swollen," Johnson said. "Some of the things in the past, it’s not the same, so we’ll what happens."
The 33-year-old Johnson has been injury plagued throughout his career and made the Orioles Opening Day roster as a non-roster invitee.