Warne takes over for Dave Urick, who went 223-99 in 23 seasons before retiring in July. The Hoyas have not reached the NCAA tournament since 2007.
In two years with the Terps, Warne served as defensive coordinator and cemented his reputation as one of the top defensive coaches in the game.
"I'm really excited to name Kevin Warne as head coach for our men's lacrosse program," Georgetown director of intercollegiate athletics Lee Reed said in a news release. "Kevin's commitment to student-athlete welfare and his passion for the game makes him the perfect person to take over our lacrosse program at this time. He is considered to be one of the top young assistants in the country and he has a terrific track record of success as an assistant coach, including appearances in the last two national championship games."
Before his two years at Maryland, Warne spent three seasons as an assistant coach at Harvard, where he worked with the Crimson defense. He previously was an associate head coach at UMBC, helping lead the team to the NCAA quarterfinals in 2007. The 2000 graduate of Hofstra also coached at Delaware and the U.S. Merchant Marine Academy.
The hiring comes after the departure of associate coach Matt Kerwick, who was widely expected to be a candidate to replace Urick, following a guilty plea in June to a DWI charge.