Cesar Delgado scored on a rebound in the 61st minute, giving CF Monterrey a 2-1 victory against the Seattle Sounders and the Group D title in CONCACAF Champions League play on Tuesday night.
The Rayados finished with 12 points in group play to earn a quarterfinal berth.
Monterrey rebounded from back-to-back losses to Seattle in late August and the Comunicaciones in mid-September that left it on the brink of not advancing.
The Sounders, after winning their first three group games that virtually assured them of a quarterfinal spot, finished second with 10 points.
A Seattle giveaway in its own defensive half led to Monterrey's game-winner. Humberto Suazo, whose long pass set up the Rayados' first goal, took the ball to the top right side of the penalty area and fired a shot that was blocked.
But the rebound came out to Delgado, who fired from just inside the top right corner of the box past Sounders goalkeeper Bryan Meredith into the left side of the net.
Dario Carreno scored for Monterrey less than three minutes into the game, his team-leading fourth Champions League goal.
Fredy Montero tied it for Seattle early in the 42nd minute with his third Champions League tally and his 18th goal of the season across Champions League, Major League Soccer and U.S. Open Cup competition.