Louis Williams added 13 points and seven assists for the Sixers, who halted a season-long five-game losing streak. They will host the Western Conference- leading Thunder on Wednesday.
Philadelphia coach Doug Collins left during the fourth quarter due to flu-like symptoms. Andre Iguodala and Jodie Meeks had 12 points apiece and Elton Brand returned from a two-game absence with 10 points, three assists and three blocks.
The Sixers won every quarter. They were up 22-20 after one, then opened the second with an 11-0 run to create space.
Young had five points during the burst and Evan Turner capped it with a short jumper for a 33-20 margin. Tayshaun Prince responded with a hook shot in the paint but Philadelphia continued to surge ahead, leading by as many as 17 in the quarter before taking a 50-34 advantage into the break.
As they did in the second, the Sixers started the third strong. They opened with a 15-5 run, taking a 65-39 lead on Brand's 14-footer at the midway point of the quarter.
The Pistons never recovered. The margin was 75-53 entering the fourth and it reached as high as 34 points before the final buzzer sounded.