The Greyhounds' Taryn VanThof scored the game's first goal, but North Carolina (14-3) scored the next five, and with a 12-8 halftime lead, put the game away with seven more.
Sophomore Annie Thomas (John Carroll) led Loyola (11-8) with five points on four goals and one assist, while junior Marlee Paton had four points on three goals and one assist.
For North Carolina, Kara Cannizzaro had a game-high seven points on five goals and two assists. Abbey Friend added four goals and two assists.
Virginia 10, No. 6 seed Georgetown 8: The visiting Cavaliers (10-9) upset the sixth-seeded Hoyas (13-5), in large part to an 8-1 run that spanned both halves.
The unseeded Cavaliers advance to the quarterfinals, where they will face No. 3 seed North Carolina next weekend.
Virginia was led offensively by Caroline McTiernan and Casey Bocklet, who scored three points each. After falling behind 1-0, the 8-1 run gave the Cavaliers an 8-2 cushion with 22:29 to play in the second half.
No. 5 Florida 16, Denver 5: The host Gators (17-2) used nine unanswered goals in the first half, sending them to the quarterfinals for the third consecutive season. They will face No. 4 seed Syracuse on Saturday.
Three Gators scored multiple goals, as senior attacker Kitty Cullen (McDonogh) tied a season high with five — making her the first Gator to score 200 in a career — and senior attacker Ashley Bruns (Mount Hebron) and sophomore midfielder Shannon Gilroy chipped in four apiece.
No. 2 Northwestern 15, Stanford 8: The two-time defending NCAA champion Wildcats (17-2) pulled away from the visiting Cardinal (14-5) thanks to dominant all-around performances from senior Taylor Thornton and junior Alyssa Leonard. The two upperclassmen each finished with four points on three goals and one assist, while Leonard also won eight draw controls to lead Northwestern to an 18-6 advantage in the circle.
Seven Wildcats found the back of the net Sunday, with Ali Cassera matching Thornton and Leonard's hat tricks, while junior Kate Macdonald and freshman Nancy Dunbar each recorded the first two-goal games of their careers.
No. 7 Penn State 12, No. 15 Massachusetts 9: Junior attacker Mackenzie Cyr (Winters Mill) notched her second straight six-point game and sophomore attacker Maggie McCormick (Liberty) recorded four goals and two assists to lead the host Nittany Lions (13-6) to a victory over the Minutewomen (18-2).
Penn State, which improved to 7-2 when hosting an NCAA tournament game, won consecutive NCAA tournament games for the first time since 1999 and advanced to the NCAA quarterfinals for the second straight year.
No. 4 Syracuse 21, Dartmouth 8: Junior Alyssa Murray tied her career high with 10 points to lead the host Orange (16-3) to a win against the Big Green (11-7).
Murray recorded five goals and a career-best five assists to spark the Orange offense. It marks just the sixth time in tournament history that a player has scored 10 or more points in a game.
Lebanon Valley 14, McDaniel 10: Four goals in a 1:43 span turned a three-goal halftime deficit into a 7-6 lead for the Flying Dutchmen (13-5) en route to a victory over the Green Terror (11-9) in the championship game of the Eastern College Athletic Conference Mid-Atlantic tournament.
Anna Beaudry and Anna Molhenrich (Mercy) led the Green Terror with three goals apiece.
Hana Krechel, who was named the tournament's Most Outstanding Player, paced the Flying Dutchmen with six assists to give her 410 points for her career to finish third all-time in Division III history.
Salisbury 8, Franklin & Marshall 6: The host Sea Gulls (20-0) advanced to their program's ninth Division III national championship weekend.
Salisbury opened both halves by scoring three straight goals, and the Diplomats (16-4) were unable to come from behind.