Towson went ahead 14-7 with 47 seconds left in the first half on West's 1-yard scoring run, which was set up by Andre Dessenberg's acrobatic 44-yard catch.
N.C. Central (2-2) scrambled into position for Oleg Parent's 33-yard field goal to close within 14-10 at the half.
Towson, which was scoreless in the first quarter for the first time this season, struck first when James Oboh leaped into the end zone to complete a 9-yard pass play from Athens with 6:39 left in the first half. It concluded a 13-play, 79-yard drive.
Moments earlier, Towson defused an N.C. Central threat when defensive end Ryan Delaire sacked Reid. Parent was wide right on the subsequent 38-yard field-goal attempt.
The Eagles got another chance with 4:29 left in the half when an N.C. Central punt hit Towson's Ryan Mays, who was blocking, and the Eagles recovered at Towson's 23-yard-line. Two plays later, Reid hit Poole open in the end zone.
NOTES: This was the first meeting between the schools in football. ... Towson was the highest-ranked Football Championship Subdivision team to ever visit O'Kelly-Riddick Stadium. The Tigers were the second ranked team to play in the stadium. The other was Bethune-Cookman in 2010. ... Towson improved to 35-14 all-time against members of the Mid-Eastern Athletic Conference, including victories on consecutive weeks after blasting Delaware State, 49-7, a week earlier. ... Peter Athens absorbed his first sack of the season in the first quarter. He was sacked three times total. ... Both teams start conference play next, with Towson going to Stony Brook next week and N.C. Central, after a week off, visiting Howard on Oct. 5 1115.
•Towson 35N.C. Central 17
TOWS—Oboh 9 pass from Athens (Evangelista kick), 6:39.
NCCU—Poole 21 pass from Reid (Parent kick), 3:45.
TOWS—West 1 run (Evangelista kick), :47.
NCCU—FG Parent 33, :02.
TOWS—West 22 run (Evangelista kick), 13:18.
TOWS—Victor 4 run (Evangelista kick), 5:09.
NCCU—Dixon 40 pass from Reid (Parent kick), 14:52.
TOWS—Victor 10 run (Evangelista kick), 1:35.