The Terps (19-3, 10-1 Atlantic Coast Conference), led by Player of the Year candidates Alyssa Thomas and Tianna Hawkins with 23 points each, won their ninth straight and the Demon Deacons (10-13, 3-8) took their fifth straight loss.
Maryland's Malina Howard made all five of her shots and finished with 12 points.
The Terps came into the game as the top rebounding team in the conference, outrebounding their opponents by more than 17 per game. Maryland beat Wake Forest on the glass 27-26. That was the fewest rebounds by the Terps all season. Their previous low was 39.
Twelve first-half turnovers allowed Maryland to build an 11-point halftime lead.
Maryland shot over 54 percent on the night while holding the Demon Deacons to 44.2 percent.
Loyola 63, Siena 51: Erik Etherly scored 25 points to lead the host Greyhounds (17-8, 9-4 Metro Atlantic Athletic Conference) past the Saints (6-18, 4-9).
Robert Olson and Dylon Cormier (Cardinal Gibbons) added 11 points apiece for Loyola, which has won two in a row after suffering back-to-back losses.
O.D. Anosike had 16 points and 16 rebounds for Siena.
Loyola led by as many as nine in the opening half, but Siena narrowed the gap over the final eight minutes. The Saints trailed by one with less than a minute to play in the half, but Etherly made a jumper to give the Greyhounds a 30-27 lead at the break.
Siena surged ahead early in the second period and again midway through the half, but Loyola responded with a 9-0 run to take a 46-37 lead on a dunk by Etherly with 9:34 remaining. Rob Poole made a 3-pointer to cut Loyola's lead to 48-42 with 8:08 to go, but the Greyhounds scored the next seven points to take a commanding 55-42 lead with just over five minutes remaining.