The Tigers (9-6) were led by senior forward Jerrelle Benimon's 20 points.
The Eagles (4-10) lost for the sixth straight time since beginning the season 4-4.
Towson led from start to finish, holding a 37-31 halftime lead. But Coppin State, last in the Mid-Eastern Athletic Conference in points allowed per game (79.1), hung around in the second half.
The Tigers opened a 13-point lead in the first half and led by as many as 14 in the second half. With about seven minutes left to play, however, the Eagles crept within 60-59 on a 3-point shot by sophomore guard Sterling Smith.
Benimon hit a 3-pointer with five minutes left, giving the Tigers a little cushion with a 66-60 lead. Towson sophomore guard Four McGlynn iced the game by making a pair of free throws with 5.3 seconds remaining. That gave Towson an 81-77 lead.
Virginia Military Institute 128, Washington College 54: QJPeterson scored a game-high 20 points and the Division I host Keydets (7-6) went on a 25-8 run in the first half and routed the visiting Shoremen (3-7).
Washington College trailed 17-10 with 15:16 left in the first half when VMI went on a 25-8 run to take a 42-18 lead with 9:15 to go in the first half. Tim Marshall sparked the run by scoring 10 of his team's 25 points. The Keydets took a 70-25 lead into halftime.
VMI outscored the Shoremen 58-20 to provide the final margin.
Kevin Cunningham led Washington College with 11 points and had nine rebounds.
Johns Hopkins 66, Valley Forge Christian 57: Jimmy Hammer had 19 points and the Blue Jays (5-6) held off a late rally by the Patriots (6-5) in the consolation game of the Juniata Invitational.
Hopkins led by as many as 11 points in the second half.
Hood 85, Elizabethtown 64: Matt Galloway and Cameron Cook (Calvert Hall) combined for 48 points, hitting six 3-pointers apiece to lead the host Blazers (8-3, 2-2 Commonwealth Conference) past the Blue Jays (4-7, 1-3).
The victory stretched the Blazers' winning streak to five straight, the longest for Hood since the 2011-12 season.
Galloway's shooting helped the Blazers build the lead in the first half, and Cook's shooting put the game out of reach in the second half.
Salisbury 64, Penn State-Harrisburg 51: Gordon Jeter and Charles Porter scored 14 points apiece to help the visiting Sea Gulls (3-6, 0-2 Capital Athletic Conference) best the Lions (5-5, 2-1).
With 7:17 left to play, Salisbury pushed the lead to double digits and never allowed Harrisburg to get closer than seven. Kenny Stone led the Lions with a game-high 17 points.
Stevenson 105, Widener 100: Alfonso Hawkins led the host Mustangs (8-2, 3-0 Middle Atlantic Conference) with 22 points to hold off the Captains (7-3, 1-2).
Widener trailed Stevenson by 20 early in the second half but managed to battle back and take a lead. Rob McPherson led the Captains with a career-best 31 points.
St. Mary's 92, Marymount 83: Nick Laguerre and Don Hill each scored 20 points to power the host Seahawks (8-3, 3-1 CAC) past the Saints (8-3, 1-2).
Johnson C. Smith 84, Bowie State 73: Ray Gatling had 15 points, but the Bulldogs (6-7, 0-2 Central Intercollegiate Athletic Association) fell behind in the second half to the host Golden Bulls (10-2, 2-0).
Christopher Newport 72, Frostburg State 59: The host Captains (10-1, 3-0 CAC) took control in the second half and led by as many as 13 points.
Jabari Kamau had 19 points for the Bobcats (0-10, 0-4).
Penn State Mont Alto 65, McDaniel 62: Andrew Merlo hit four straight free throws after a technical foul to pull the visiting Green Terror (7-4) within one with six seconds remaining. A second later, Bobby Ingram made two free throws and the Lions (12-0) won.
Baltimore Sun staff contributed to this article.