Max Pfeifer led the way with two goals and two assists for the Fighting Irish (1-0). The win marks the third straight for Notre Dame against the Blue Devils (1-1) in regular-season games.
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John Kemp made 14 saves for the Irish and Dan Wigrizer had 16 for Duke.
No. 2 Virginia 9, Drexel 8: Trailing 8-7 with less than eight minutes to play, the Cavaliers (1-0) scored twice to beat the host Dragons (0-1). Bobby Hill scored the tying goal at 7:58 and the game-winner came from Rob Emery, his second, with 4:48 left.
Colin Briggs had a goal and two assists for the Cavaliers. Nick Trizano and Brendan Glynn each scored twice for Drexel.
No. 6 North Carolina 18, Detroit 8: R.G. Keenan won 16 of 18 faceoffs as the host Tar Heels (3-0) routed the Titans (1-3).
Carolina extended its 8-3 halftime lead with an 8-2 run in the third quarter. Jimmy Dunster led the Heels with a hat trick.
No. 8 Villanova 17, Lehigh 7: The visiting Wildcats (1-0) scored 10 unanswered goals in the second half to beat the Mountain Hawks (1-1). Kevin Cunningham scored five goals and Will Casertano had four for Villanova.
No. 9 UMass 11, No. 17 Bucknell 9: The host Minutemen (2-0) used a 3-1 run in the second quarter to get the lead and matched the Bison (0-2) goal for goal in the other quarters. Will Manny and Kyle Smith each scored three goals for UMass.
Robert Morris 10, UMBC 8: Scott Jones scored twice, but the host Retrievers (0-1) saw their comeback bid fall short. Jones' second goal tied the score at 8-8 with 10:19 left, but the Colonials (2-0) scored the next two.
Robert Morris opened with a 2-0 lead, but UMBC answered to tie the score at 2 just 38 seconds into the second quarter. Both teams scored twice in the third, but Robert Morris won the only draw of the fourth quarter and Jacob Ruest scored to give the Colonials the lead.
Salisbury 16, Lynchburg 7: Sam Bradman had four goals and two assists to power the host Sea Gulls (2-0) past the Hornets (1-1).
The Sea Gulls took a 2-0 lead 90 seconds into the game. Salisbury extended its 6-3 halftime lead by outscoring Lynchburg 7-2.
Goucher 27, Southwestern 7: Kyle Boncaro scored seven goals to power the visiting Gophers (1-0) past the Pirates (0-1). Goucher led 14-0 at the half
Stevenson 11, Haverford 5: Stephen Banick had two goals and five assists to lead the host Mustangs (1-0) past the Fords (0-1). Stevenson led 4-1 at the half before going on a 5-3 run in the third quarter.
McDaniel 11, Kenyon 6: The host Green Terror (1-0) finished with a 5-0 run in the fourth quarter to beat the Lords (0-1).
Catholic 7, Hood 3: Brendan Englert scored four goals to lead the visiting Cardinals (1-0) past the Blazers (0-1). Hood's goals came from Scott Thompson, Trey Freeman and James Weger.
No. 11 Virginia 14, No. 7 Loyola 9: The host Cavaliers (1-0) won their first season opener in three years and avenged two straight losses to the Greyhounds (0-1).
Ainsley Baker matched her career-high five goals and Josie Owen had a goal and six assists for Virginia, which outscored Loyola 8-4 in the second half. Hannah Schmitt led the Greyhounds with three goals.
Johns Hopkins 19, George Mason 6: Candace Rossi scored a game-high five goals, including her 100th career, and Colleen McCaffrey added four goals to power the visiting Blue Jays (1-0) past the Patriots (1-1).
Hopkins used a 7-1 run that spanned both halves to turn a tie game into a six-goal lead. Hopkins outscored Mason 13-2 in the second half.
Navy 20, Longwood 4: Freshman Jess Fellows scored six goals to power the host Mids (2-1) over the Lancers (0-1). Navy won 19 of 26 draws and led 8-3 at halftime.
Navy held a 25-16 advantage in ground balls and 39-18 in shots. Kathy Young added four goals and one assist for the Mids.
Hood 17, Waynesburg 16: Kati Vu and freshman Bailey Czech each had five goals and five assists to power the visiting Blazers (1-0) past the Yellow Jackets (0-1).