The line opened Sunday with the Ravens as 3 1/2-point favorites, but has since widened with Browns quarterback Robert Griffin III's move to the injured reserve after a shoulder injury. Griffin was hurt during the Browns' 29-10 loss to the Philadelphia Eagles on Sunday.
The over-under for the game is 43.5 points.
The Ravens were three-point favorites over the Buffalo Bills, a spread they covered with a 13-7 home victory. The over-under for the season opener was 44; the combined final score didn't reach even half of that.