Protozoa had been based at Paramount since 2011. The only project to come from that deal is "Noah," starring Russell Crowe in the title role with Protozoa and New Regency producing the $175 million project.
Paramount launches "Noah" on March 28.
Aronofsky signed a first-look deal with Arnon Milchan's New Regency in 2003, leading to the 2006 drama "The Fountain." He's also signed a TV deal with HBO.
"It is a thrill to be re-teaming with my old friends at New Regency," Aronofsky said. "Arnon has been a great supporter since we made The Fountain together. It is a golden age for the small screen and moving into that realm with HBO as partners is a dream come true."
Aronofsky is the second major filmmaker to leave Paramount and sign with New Regency within a month. After an eight-year run at Paramount, Brad Pitt's Plan B announced on Dec. 10 that it had signed a three-year deal with New Regency and RatPac Entertainment.
Deadline Hollywood first reported the Aronofsky news.
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