Producers are Larry Rattner, Sig De Miguel and Ally Walker, who is also directing and scripting.
Chase will portray a formerly supremely fit soldier just back from Iraq who's in rapid decline from pancreatic cancer. Blair will play his wife.
Chase has been set to star in the third season of A&E's "Longmire." His other credits include "Damages," "Saving Grace" and the upcoming drama "Tao of Surfing."
Blair was the female lead in "Anger Management" for two seasons until departing in June amid reports of friction with Charlie Sheen. Grenier is known primarily for his role on TV's "Entourage"; a feature version based on the series is in limbo.
Chase, Blair and Grenier are represented by Gersh. Chase is managed by Untitled Entertainment.
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