C.J. Spiller (229 yards rushing in last four games vs. Dolphins) has had great success as a runner and receiver against the Dolphins. Fred Jackson (75 carries, 344 yards, 4.6 yards per carry) is having a good season. But the Dolphins counter with the NFL's best three-man defensive tackle trio among Jared Odrick, Randy Starks and Paul Soliai. There's a concern because middle linebacker Dannell Ellerbe (shoulder) might not play. The Dolphins are 15th in rushing yards per game allowed (105.2) while the Bills, a running team, are third in rushing yards per game (148.8). This matchup will be a key to victory. Look for the Dolphins to clamp down.