With a playoff berth on the line, Catonsville pounded out 318 yards rushing and forced four Parkville turnovers en route to a 32-6 Comet victory.
On senior night, the Comets (7-3) guaranteed a playoff berth in the Class 4A North Region standings and they moved up to a third seed by virtue of Blake's 28-20 loss to Sherwood.
Westminster is the top seed in the playoffs.
Catonsville is in the playoffs for the third year in a row and sixth season in coach Rich Hambor's tenure as head coach.
"I told the seniors before the game they had a chance to do something special and they took that to heart," Catonsville coach Rich Hambor said.
Seniors DeAndre’ Lane (14 carries, 103 yards) and Joseth Hylton (7 carries, 33 yards) and Julian Singletary (7 carries, 48 yards) did most of the damage on the ground.
They were running behind an offensive line that included center Jake Faircloth, guards Brandon Dixon and Zach Delker, tackles Mason Klompus and Julian Robinson and tight end Teddy Crayton.
Catonsville struck first on an 11-play 61-yard drive that ended with a one-yard plunge by Lane.
Big plays on the drive were a 16-yard run by Singletary and a 20-yard pass from quarterback Justin Sprankle to Lane.
"Me and Joseth have been switching off between the Eight-back and the Seven-back and I was the 7 on that play," Lane said.
The extra point was wide and the Comets led 6-0.
Parkville (5-5) drove 42 yards to the Comets 23-yard line on its opening drive, thanks to strong running from Otis Pullen, but the drive ended when Catonsville defensive end TJ Henry picked up a bad shotgun snap and ran 72 yards for a touchdown.
"I just saw the ball hit his hands and bounce down and I'm thinking its senior night do it big so I just ran for my life," Henry said. "It was an amazing feeling."
The Comets led 12-0 after the extra point was blocked.
Parkville committed three turnovers in the first and, although Nigel Minter’s fumble recovery didn’t lead to any Comet points, an interception and 36-yard return by Tyrone Ali led to a 20-yard touchdown sweep by Lane three players later.
Garrett Wack’s extra point made it 19-0 with 2:37 left until halftime.
Parkville ran 32 plays and had 100 yards in the first half.
Otis Pullen ran for 43 yards during the opening 24 minutes.
Lane had 57 yards rushing and Hylton and Singletary combined for 62 yards in the opening half.
Singletary added a 1-yard touchdown and Andre Henderson carried one to paydirt from 17 yards out in the fourth quarter.
The Comets had 14 different players carry the ball for positive yardage, including senior linemen Cheldon Simon (17 yards) and Mason Klompus (78).
Parkville's Thomas Brown scored the Knights only touchdown with 12 seconds left in the game.
Last year the Comets won tow playoff games before getting eliminated by Old Mill in the state semifinals.
"This is a great feeling to know we've gone to the playoffs three years in a row and I know I can be a part of it so I'm hoping this year we can actually finish and get a state championship," Lane said.