State Police in Cumberland County are investigating a Tuesday night fatal accident. Police say the crash happened just before midnight along Interstate 81 South in Hampden Township.

Police say the vehicle left the roadway, traveled down an embankment and hit a tree. Police say a front- seat; female passenger from Chambersburg was killed in the crash.

Police say the driver was extracted from the vehicle by crews and taken to Chambersburg Hospital with moderate injuries. A rear- seat passenger was also extracted and taken to Penn State Hershey Medical Center with serious injuries and is on a respirator at last check.

Police say poor driving conditions may have played a role in the crash.

FOX43 will bring you more information about the crash as it is made available.