Born in Baltimore, she was the daughter of William J. Mooney, an accountant, and Dorothy Hermann Mooney, a retired Gilman School teacher.
Raised in Pinehurst, she was a 2001 Roland Park Country School graduate. She earned a cum laude degree in international relations from Boston University. As an undergraduate, she studied in Dublin, Ireland. She was a speechwriter for a member of the European Parliament, Proinsias De Rossa, family members said.
She was also a John F. Kennedy Presidential Library and Museum intern and worked on the selection process for the annual Profiles in Courage award.
While in Boston, she met her husband, Alex Spence. They were married in Baltimore in 2009.
Mrs. Spence was diagnosed with breast cancer in 2005. She then became a national sales and service coordinator with Event 360, a firm that stages large fundraising events.
Family members said she worked almost exclusively in the planning and coordination of events for the Susan G. Komen Foundation.
Her brother, Daniel W. Mooney of Baltimore, said that she coordinated and walked three-day events in Boston, Washington, San Diego and other cities across the country.
He said she was a speaker at Komen conferences and fundraising events, including a 2011 Dallas meeting.
"Bridget became a fixture at our Global Race in Washington, D.C., always with a ready smile, a boundless optimism, and a burning desire to spread the word about breast cancer in young women," said Nancy Brinker, chief executive officer of Susan G. Komen for the Cure.
She was a member of the Komen Young Women's Advisory Council. She appeared on national television advertisements for Susan Komen. She was interviewed for "60 Minutes" and was profiled in magazines.
She was the recipient of the 2009 Boston University Young Alumna Award.
A Mass will be held at 11 a.m. Tuesday at St. Ignatius Roman Catholic Church, 740 Calvert St., where she was married.
In addition to her brother, husband and mother, surivivors in include and two other brothers, Patrick J. Mooney of Baltimore and John H. Mooney of Washington, D.C. Her father died in 2008.