The accident occurred in the 2900 block of Dublin Road (Route 440) near Poplar Road at 12:03 a.m., according to the duty officer at the Bel Air Barrack.
The vehicle ran off the road and hit a tree. Harford Fire Blog on Facebook reported the victim was in grave condition when paramedics arrived on the scene.
The victim, identified as Charles Garland Jr. of Whiteford, was taken by Darlington Volunteer Fire Company ambulance to Upper Chesapeake Medical Center in Bel Air, where he was pronounced dead, the duty officer said. She said she could not provide any additional details about the victim.
The accident remains under investigation.
Friday's fatality was the seventh this year on Harford County roads.