Hogan posted on his Facebook page a photo of himself flexing his biceps in a Baltimore hospital room, a chemotherapy machine feeding drugs into a port in his chest.
"I can't tell you how it feels to be getting my very last chemo treatment," Hogan wrote. "I plan to make the most of every single day I am given, and I won't stop fighting until a cure is discovered for this terrible disease."
Hogan stunned the state in June 2015 when he announced he had Stage 3 non-Hodgkin's lymphoma, saying that doctors had found more than 60 tumors throughout his body just days earlier.
He publicly documented the aggressive 18-week treatment of the disease, and announced afterward in November 2015 that a scan showed he was "100 percent cancer free."
The chemotherapy, however, continued once a month in what doctors called a maintenance regime to help ensure Hogan was in remission.
On Monday, First Lady Yumi Hogan snipped off the lime green "Hogan Strong" bracelet the Republican governor has worn since his diagnosis, Hogan aides said. The governor snipped off the bracelet worn by his wife, and later cut away bracelets worn by his senior staff.
Hogan has undergone treatment at the University of Maryland's Greenebaum Cancer Center in Baltimore. Aides have said he had worked from his hospital room and convened cabinet meetings there.
In a Facebook video of Hogan's return to the governor's mansion, he governor told staffers Monday, "It's been a heck of a year to have."