"There is a holiness about the Constitution. The peace and prosperity of this Republic, the world's last best hope, must not be haphazarded, much less destroyed, that certain men may rule." — Hezekiah Niles,1828.

The name of Hezekiah Niles is about as far astern as it gets these days, and if it resonates at all, it is probably with historians, professors and students of early 19th-century American history who closet themselves in libraries while poring through dusty bound volumes of his Niles' Register.

But the Niles' Register, which was published in Baltimore and exerted a powerful influence on the early national discourse, was the nation's first weekly newsmagazine.

Niles was born in East Bradford, Chester County, Pa., on Oct. 10, 1777, to a Quaker family. His father was a carpenter and his mother was the daughter of a wealthy Wilmington, Del., merchant.

He attended Friends School in Wilmington before being apprenticed at 17 to Benjamin Johnson, a Philadelphia printer-bookseller.

Niles formed a partnership with Vincent Bonsal, and the two established the printing and publishing firm of Bonsal and Niles in Wilmington. Bonsal also had a print shop in Baltimore.

The firm collapsed in 1799 after an ill-fated venture left Niles $25,000 in debt and bereft of a partner who took the money and vanished.

"Bonsal peace to his soul! — was a bad man. I knew it too late," Niles wrote to a friend years later.

Undaunted, Niles pressed on and established The Apollo, or Delaware Weekly Magazine, and he generated most of the copy.

Niles closed the weekly and left Wilmington in 1805 for Baltimore, where he opened the Evening Post, which lasted until 1811.

Niles didn't stay out of publishing very long. He introduced the Weekly Register, whose first number rolled out of his Water Street print shop on Sept. 7, 1811, 200 years ago this week. He later renamed it Niles' Register.

The Register, which sprang into life with a national circulation of 1,500 readers, put Baltimore on the map as a news center and made its owner-editor a famous man.

In an era with a high casualty rate for periodicals, Niles managed to hang on mainly because his 16-page periodical — which had no illustrations and whose masthead was graced with the motto, "The Past, The Present, For the Future" — arrived on time to readers who paid $5 a year for a subscription.

He charted his publication's course when he wrote that he was "to write for and speak to people — not the learned and wealthy … but the free laboring people, like ourselves, struggling to get a little forward in the world, and educate their children et cetera."

He refused to carry any advertising in the publication for fear it would compromise his ability to write about what he wanted.

"It was perhaps the most widely circulated magazine of the era," wrote Bill Kovarik, a former Baltimore Sun copy editor who is now a historian and professor of journalism at Radford University in Virginia.

Circulation eventually rose and stayed at 4,000 for 25 years.

Niles, Kovarik reported, never took a vacation from his publication.

What drew readers in was his ability to speak directly to them and to be objective in an era when that was far from common.

During the War of 1812 after the British had burned Washington and headed for Baltimore, Niles wrote, "with feelings that cannot be uttered, we devote a considerable portion of the present number of the Register to publish and preserve a body of facts and evidence regarding the proceedings of the enemy at Hampton, that will forever disgrace the British name. Shuddering humanity outlaws the finished villains. …"